(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma

Although Wnt/β-catenin signaling is known to be aberrantly activated in PDAC, mutations of CTNNB1, APC or other pathway components are rare in this tumor type, suggesting alternative mechanisms for Wnt/β-catenin activation. Recent studies have implicated the (pro)renin receptor ((P)RR) is related to...

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Published in:Sci Rep
Main Authors: Shibayama, Yuki, Fujimori, Takayuki, Nguyen, Genevieve, Hirose, Takuo, Totsune, Kazuhito, Ichihara, Atsuhiro, Kitada, Kento, Nakano, Daisuke, Kobori, Hiroyuki, Kohno, Masakazu, Masaki, Tsutomu, Suzuki, Yasuyuki, Yachida, Shinichi, Nishiyama, Akira
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352858/
https://ncbi.nlm.nih.gov/pubmed/25747895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08854
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