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Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Thousands of interactions assemble proteins into modules that impart spatial and functional organization to the cellular proteome. Through affinity-purification mass spectrometry, we have created two proteome-scale, cell-line-specific interaction networks. The first, BioPlex 3.0, results from affini...

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Pubblicato in:Cell
Autori principali: Huttlin, Edward L., Bruckner, Raphael J., Navarrete-Perea, Jose, Cannon, Joe R., Baltier, Kurt, Gebreab, Fana, Gygi, Melanie P., Thornock, Alexandra, Zarraga, Gabriela, Tam, Stanley, Szpyt, John, Gassaway, Brandon M., Panov, Alexandra, Parzen, Hannah, Fu, Sipei, Golbazi, Arvene, Maenpaa, Eila, Stricker, Keegan, Thakurta, Sanjukta Guha, Zhang, Tian, Rad, Ramin, Pan, Joshua, Nusinow, David P., Paulo, Joao A., Schweppe, Devin K., Vaites, Laura Pontano, Harper, J. Wade, Gygi, Steven P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8165030/
https://ncbi.nlm.nih.gov/pubmed/33961781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2021.04.011
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