Systematic Analysis of Human Cells Lacking ATG8 Proteins Uncovers Roles for GABARAPs and the CCZ1/MON1 Regulator C18orf8/RMC1 in Macroautophagic and Selective Autophagic Flux

Selective autophagy and macroautophagy sequester specific organelles/substrates or bulk cytoplasm, respectively, inside autophagosomes as cargo for delivery to lysosomes. The mammalian ATG8 orthologues (MAP1LC3A/B/C and GABARAP/L1/L2) are ubiquitin (UB)-like proteins conjugated to the autophagosome...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Vaites, Laura Pontano, Paulo, Joao A., Huttlin, Edward L., Harper, J. Wade
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5730722/
https://ncbi.nlm.nih.gov/pubmed/29038162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00392-17
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