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Exploring modular reengineering strategies to redesign the teicoplanin non-ribosomal peptide synthetase
Non-ribosomal peptide synthesis is an important biosynthesis pathway in secondary metabolism. In this study we have investigated modularisation and redesign strategies for the glycopeptide antibiotic teicoplanin. Using the relocation or exchange of domains within the NRPS modules, we have identified...
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| Publicado no: | Chem Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society of Chemistry
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8162109/ https://ncbi.nlm.nih.gov/pubmed/34094211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc03483e |
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