A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics

Non-ribosomal peptide biosynthesis produces highly diverse natural products through a complex cascade of enzymatic reactions that together function with high selectivity to produce bioactive peptides. The modification of non-ribosomal peptide synthetase (NRPS)-bound amino acids can introduce signifi...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Kaniusaite, Milda, Tailhades, Julien, Marschall, Edward A., Goode, Robert J. A., Schittenhelm, Ralf B., Cryle, Max J.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2019
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6993612/
https://ncbi.nlm.nih.gov/pubmed/32055321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc03678d
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