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Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis
Halogenation plays a significant role in the activity of the glycopeptide antibiotics (GPAs), although up until now the timing and therefore exact substrate involved was unclear. Here, we present results combined from in vivo and in vitro studies that reveal the substrates for the halogenase enzymes...
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| 出版年: | Chem Sci |
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| 主要な著者: | , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Royal Society of Chemistry
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5620994/ https://ncbi.nlm.nih.gov/pubmed/28989629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc00460e |
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