Halogenation of glycopeptide antibiotics occurs at the amino acid level during non-ribosomal peptide synthesis

Halogenation plays a significant role in the activity of the glycopeptide antibiotics (GPAs), although up until now the timing and therefore exact substrate involved was unclear. Here, we present results combined from in vivo and in vitro studies that reveal the substrates for the halogenase enzymes...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Kittilä, Tiia, Kittel, Claudia, Tailhades, Julien, Butz, Diane, Schoppet, Melanie, Büttner, Anita, Goode, Rob J. A., Schittenhelm, Ralf B., van Pee, Karl-Heinz, Süssmuth, Roderich D., Wohlleben, Wolfgang, Cryle, Max J., Stegmann, Evi
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620994/
https://ncbi.nlm.nih.gov/pubmed/28989629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc00460e
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