Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines, condensation domains perform the central function of chain assembly, typically by forming a peptide bond between two peptidyl carrier protein (PCP)...

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Publicado no:Nat Commun
Main Authors: Izoré, Thierry, Candace Ho, Y. T., Kaczmarski, Joe A., Gavriilidou, Athina, Chow, Ka Ho, Steer, David L., Goode, Robert J. A., Schittenhelm, Ralf B., Tailhades, Julien, Tosin, Manuela, Challis, Gregory L., Krenske, Elizabeth H., Ziemert, Nadine, Jackson, Colin J., Cryle, Max J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097023/
https://ncbi.nlm.nih.gov/pubmed/33947858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22623-0
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