Structures of a non-ribosomal peptide synthetase condensation domain suggest the basis of substrate selectivity

Non-ribosomal peptide synthetases are important enzymes for the assembly of complex peptide natural products. Within these multi-modular assembly lines, condensation domains perform the central function of chain assembly, typically by forming a peptide bond between two peptidyl carrier protein (PCP)...

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Pubblicato in:Nat Commun
Autori principali: Izoré, Thierry, Candace Ho, Y. T., Kaczmarski, Joe A., Gavriilidou, Athina, Chow, Ka Ho, Steer, David L., Goode, Robert J. A., Schittenhelm, Ralf B., Tailhades, Julien, Tosin, Manuela, Challis, Gregory L., Krenske, Elizabeth H., Ziemert, Nadine, Jackson, Colin J., Cryle, Max J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097023/
https://ncbi.nlm.nih.gov/pubmed/33947858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22623-0
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