Whole-Body Prolyl Hydroxylase Domain (PHD) 3 Deficiency Increased Plasma Lipids and Hematocrit Without Impacting Plaque Size in Low-Density Lipoprotein Receptor Knockout Mice

Background and aims: Atherosclerosis is an important cause of clinical cardiovascular events. Atherosclerotic plaques are hypoxic, and reoxygenation improves plaque phenotype. Central players in hypoxia are hypoxia inducible factors (HIF) and their regulators, HIF-prolyl hydroxylase (PHD) isoforms 1...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Demandt, Jasper A. F., van Kuijk, Kim, Theelen, Thomas L., Marsch, Elke, Heffron, Sean P., Fisher, Edward A., Carmeliet, Peter, Biessen, Erik A. L., Sluimer, Judith C.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8160238/
https://ncbi.nlm.nih.gov/pubmed/34055796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.664258
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