Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

The regulation of neutrophil lifespan by induction of apoptosis is critical for maintaining an effective host response and preventing excessive inflammation. The hypoxia-inducible factor (HIF) oxygen-sensing pathway has a major effect on the susceptibility of neutrophils to apoptosis, with a marked...

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Detalhes bibliográficos
Principais autores: Walmsley, Sarah R., Chilvers, Edwin R., Thompson, Alfred A., Vaughan, Kathryn, Marriott, Helen M., Parker, Lisa C., Shaw, Gary, Parmar, Selina, Schneider, Martin, Sabroe, Ian, Dockrell, David H., Milo, Marta, Taylor, Cormac T., Johnson, Randall S., Pugh, Christopher W., Ratcliffe, Peter J., Maxwell, Patrick H., Carmeliet, Peter, Whyte, Moira K.B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049381/
https://ncbi.nlm.nih.gov/pubmed/21317538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43273
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