Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

The regulation of neutrophil lifespan by induction of apoptosis is critical for maintaining an effective host response and preventing excessive inflammation. The hypoxia-inducible factor (HIF) oxygen-sensing pathway has a major effect on the susceptibility of neutrophils to apoptosis, with a marked...

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Main Authors: Walmsley, Sarah R., Chilvers, Edwin R., Thompson, Alfred A., Vaughan, Kathryn, Marriott, Helen M., Parker, Lisa C., Shaw, Gary, Parmar, Selina, Schneider, Martin, Sabroe, Ian, Dockrell, David H., Milo, Marta, Taylor, Cormac T., Johnson, Randall S., Pugh, Christopher W., Ratcliffe, Peter J., Maxwell, Patrick H., Carmeliet, Peter, Whyte, Moira K.B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049381/
https://ncbi.nlm.nih.gov/pubmed/21317538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43273
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