Overall Retention of Methyl Stereochemistry during B(12)-Dependent Radical SAM Methyl Transfer in Fosfomycin Biosynthesis

[Image: see text] Methylcobalamin-dependent radical S-adenosylmethionine (SAM) enzymes methylate non-nucleophilic atoms in a range of substrates. The mechanism of the methyl transfer from cobalt to the receiving atom is still mostly unresolved. Here we determine the stereochemical course of this pro...

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Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: McLaughlin, Martin I., Pallitsch, Katharina, Wallner, Gabriele, van der Donk, Wilfred A., Hammerschmidt, Friedrich
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2021
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8158854/
https://ncbi.nlm.nih.gov/pubmed/33942609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.1c00113
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