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On the Stereochemistry of 2-Hydroxyethylphosphonate Dioxygenase

[Image: see text] Stereochemical investigations have shown that the conversion of 2-hydroxyethylphosphonate to hydroxymethylphosphonate by the enzyme HEPD involves removal of the pro-S hydrogen at C2 and, surprisingly, the loss of stereochemical information at C1. As a result, the mechanisms previou...

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Detalhes bibliográficos
Main Authors: Whitteck, John T., Malova, Petra, Peck, Spencer C., Cicchillo, Robert M., Hammerschmidt, Friedrich, van der Donk, Wilfred A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069692/
https://ncbi.nlm.nih.gov/pubmed/21381767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1113326
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