O–H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase

[Image: see text] Activation of O–H bonds by inorganic metal-oxo complexes has been documented, but no cognate enzymatic process is known. Our mechanistic analysis of 2-hydroxyethylphosphonate dioxygenase (HEPD), which cleaves the C1–C2 bond of its substrate to afford hydroxymethylphosphonate on the...

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Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Peck, Spencer C., Wang, Chen, Dassama, Laura M. K., Zhang, Bo, Guo, Yisong, Rajakovich, Lauren J., Bollinger, J. Martin, Krebs, Carsten, van der Donk, Wilfred A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302023/
https://ncbi.nlm.nih.gov/pubmed/28092705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b12147
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