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Stereospecific Radical-Mediated B(12)-Dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3
Fom3, the antepenultimate enzyme in the fosfomycin biosynthetic pathway in Streptomyces spp., is a class B cobalamin-dependent radical SAM methyltransferase that catalyzes methylation of (5′-cytidylyl)-2-hydroxyethylphosphonate (2-HEP-CMP) to form (5′-cytidylyl)-2-hydroxypropylphosphonate (2-HPP-CMP...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6103835/ https://ncbi.nlm.nih.gov/pubmed/29969250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00616 |
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