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Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads

The broad-spectrum phosphonate antibiotic fosfomycin is currently in use for clinical treatment of infections caused by both Gram-positive and Gram-negative uropathogens. The antibiotic is biosynthesized by various streptomycetes, as well as by pseudomonads. Notably, the biosynthetic strategies used...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Olivares, Philip, Ulrich, Emily C., Chekan, Jonathan R., van der Donk, Wilfred A., Nair, Satish K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315633/
https://ncbi.nlm.nih.gov/pubmed/27977135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00939
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