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Structural Basis for Methyl Transfer by a Radical SAM Enzyme
The radical SAM (RS) enzymes RlmN and Cfr methylate 23S ribosomal RNA, modifying the C2 or C8 position of adenosine 2503. The methyl groups are installed by a two-step sequence involving initial methylation of a conserved Cys residue (RlmN Cys 355) by SAM. Methyl transfer to the substrate requires r...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3506250/ https://ncbi.nlm.nih.gov/pubmed/21527678 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1205358 |
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