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Structural basis for non-radical catalysis by TsrM, a radical-SAM methylase
TsrM methylates C2 of the indole ring of L-tryptophan (Trp) during the biosynthesis of the quinaldic acid moiety of thiostrepton. It is annotated as a cobalamin-dependent radical S-adenosylmethionine (SAM) methylase; however, TsrM does not reductively cleave SAM to the universal 5ʹ-deoxyadenosyl 5ʹ-...
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| Pubblicato in: | Nat Chem Biol |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7990684/ https://ncbi.nlm.nih.gov/pubmed/33462497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-00717-y |
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