Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA

RlmN is a dual-specificity RNA methylase that modifies C2 of adenosine 2503 (A2503) in 23S rRNA and C2 of adenosine 37 (A37) in several Escherichia coli tRNAs. A related methylase, Cfr, modifies C8 of A2503 by a similar mechanism, conferring resistance to multiple classes of antibiotics. Herein, we...

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Bibliographic Details
Published in:Science
Main Authors: Schwalm, Erica L., Grove, Tyler L., Booker, Squire J., Boal, Amie K.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5629962/
https://ncbi.nlm.nih.gov/pubmed/27081063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad5367
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