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Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA
RlmN is a dual-specificity RNA methylase that modifies C2 of adenosine 2503 (A2503) in 23S rRNA and C2 of adenosine 37 (A37) in several Escherichia coli tRNAs. A related methylase, Cfr, modifies C8 of A2503 by a similar mechanism, conferring resistance to multiple classes of antibiotics. Herein, we...
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| Publicado no: | Science |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5629962/ https://ncbi.nlm.nih.gov/pubmed/27081063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad5367 |
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