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Reconstitution and substrate specificity of the radical SAM thiazole C-methyltransferase in thiomuracin biosynthesis

Thiomuracin is a thiopeptide antibiotic with potent activity towards Gram-positive drug-resistant bacteria. Thiomuracin is biosynthesized from a precursor peptide, TbtA, by a complex array of posttranslational modifications. One of several intriguing transformations is the C-methylation of thiazole,...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Mahanta, Nilkamal, Zhang, Zhengan, Hudson, Graham A., van der Donk, Wilfred A., Mitchell, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5477235/
https://ncbi.nlm.nih.gov/pubmed/28301141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b00693
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