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Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase

[Image: see text] The past decade has seen the discovery of four different classes of radical S-adenosylmethionine (rSAM) methyltransferases that methylate unactivated carbon centers. Whereas the mechanism of class A is well understood, the molecular details of methylation by classes B–D are not. In...

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Pubblicato in:J Am Chem Soc
Autori principali: Zhang, Zhengan, Mahanta, Nilkamal, Hudson, Graham A., Mitchell, Douglas A., van der Donk, Wilfred A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2017
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748327/
https://ncbi.nlm.nih.gov/pubmed/29190095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b10203
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