Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

Cardiac arrhythmias are the most common cause of sudden cardiac death worldwide. Lengthening the ventricular action potential duration (APD), either congenitally or via pathologic or pharmacologic means, predisposes to a life-threatening ventricular arrhythmia, Torsade de Pointes. I(Ks) (KCNQ1+KCNE1...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Lin, Yangyang, Grinter, Sam Z., Lu, Zhongju, Xu, Xianjin, Wang, Hong Zhan, Liang, Hongwu, Hou, Panpan, Gao, Junyuan, Clausen, Chris, Shi, Jingyi, Zhao, Wenshan, Ma, Zhiwei, Liu, Yongfeng, White, Kelli McFarland, Zhao, Lu, Kang, Po Wei, Zhang, Guohui, Cohen, Ira S., Zou, Xiaoqin, Cui, Jianmin
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157969/
https://ncbi.nlm.nih.gov/pubmed/33990467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024215118
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