Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

Cardiac arrhythmias are the most common cause of sudden cardiac death worldwide. Lengthening the ventricular action potential duration (APD), either congenitally or via pathologic or pharmacologic means, predisposes to a life-threatening ventricular arrhythmia, Torsade de Pointes. I(Ks) (KCNQ1+KCNE1...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Lin, Yangyang, Grinter, Sam Z., Lu, Zhongju, Xu, Xianjin, Wang, Hong Zhan, Liang, Hongwu, Hou, Panpan, Gao, Junyuan, Clausen, Chris, Shi, Jingyi, Zhao, Wenshan, Ma, Zhiwei, Liu, Yongfeng, White, Kelli McFarland, Zhao, Lu, Kang, Po Wei, Zhang, Guohui, Cohen, Ira S., Zou, Xiaoqin, Cui, Jianmin
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8157969/
https://ncbi.nlm.nih.gov/pubmed/33990467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2024215118
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