Deletion of cytosolic gating ring decreases gate and voltage sensor coupling in BK channels

Large conductance Ca(2+)-activated K(+) channels (BK channels) gate open in response to both membrane voltage and intracellular Ca(2+). The channel is formed by a central pore-gate domain (PGD), which spans the membrane, plus transmembrane voltage sensors and a cytoplasmic gating ring that acts as a...

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Udgivet i:J Gen Physiol
Main Authors: Zhang, Guohui, Geng, Yanyan, Jin, Yakang, Shi, Jingyi, McFarland, Kelli, Magleby, Karl L., Salkoff, Lawrence, Cui, Jianmin
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5339509/
https://ncbi.nlm.nih.gov/pubmed/28196879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611646
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