Coupling of Ca(2+) and voltage activation in BK channels through the αB helix/voltage sensor interface

Large-conductance Ca(2+) and voltage-activated K(+) (BK) channels control membrane excitability in many cell types. BK channels are tetrameric. Each subunit is composed of a voltage sensor domain (VSD), a central pore-gate domain, and a large cytoplasmic domain (CTD) that contains the Ca(2+) sensors...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Geng, Yanyan, Deng, Zengqin, Zhang, Guohui, Budelli, Gonzalo, Butler, Alice, Yuan, Peng, Cui, Jianmin, Salkoff, Lawrence, Magleby, Karl L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7321994/
https://ncbi.nlm.nih.gov/pubmed/32513714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1908183117
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