Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

In voltage-activated ion channels, voltage sensor (VSD) activation induces pore opening via VSD-pore coupling. Previous studies show that the pore in KCNQ1 channels opens when the VSD activates to both intermediate and fully activated states, resulting in the intermediate open (IO) and activated ope...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Hou, Panpan, Eldstrom, Jodene, Shi, Jingyi, Zhong, Ling, McFarland, Kelli, Gao, Yuan, Fedida, David, Cui, Jianmin
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700111/
https://ncbi.nlm.nih.gov/pubmed/29167462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01911-8
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