Inactivation of KCNQ1 potassium channels reveals dynamic coupling between voltage sensing and pore opening

In voltage-activated ion channels, voltage sensor (VSD) activation induces pore opening via VSD-pore coupling. Previous studies show that the pore in KCNQ1 channels opens when the VSD activates to both intermediate and fully activated states, resulting in the intermediate open (IO) and activated ope...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Hou, Panpan, Eldstrom, Jodene, Shi, Jingyi, Zhong, Ling, McFarland, Kelli, Gao, Yuan, Fedida, David, Cui, Jianmin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5700111/
https://ncbi.nlm.nih.gov/pubmed/29167462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01911-8
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