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ML277 specifically enhances the fully activated open state of KCNQ1 by modulating VSD-pore coupling
Upon membrane depolarization, the KCNQ1 potassium channel opens at the intermediate (IO) and activated (AO) states of the stepwise voltage-sensing domain (VSD) activation. In the heart, KCNQ1 associates with KCNE1 subunits to form I(Ks) channels that regulate heart rhythm. KCNE1 suppresses the IO st...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6684268/ https://ncbi.nlm.nih.gov/pubmed/31329101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.48576 |
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