Domain–domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channel

Voltage-gated ion channels generate electrical currents that control muscle contraction, encode neuronal information, and trigger hormonal release. Tissue-specific expression of accessory (β) subunits causes these channels to generate currents with distinct properties. In the heart, KCNQ1 voltage-ga...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Zaydman, Mark A, Kasimova, Marina A, McFarland, Kelli, Beller, Zachary, Hou, Panpan, Kinser, Holly E, Liang, Hongwu, Zhang, Guohui, Shi, Jingyi, Tarek, Mounir, Cui, Jianmin
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2014
Fag:
Biophysics and Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381907/
https://ncbi.nlm.nih.gov/pubmed/25535795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03606
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