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Insights into the mismatch discrimination mechanism of Y-family DNA polymerase Dpo4
Nucleobases within DNA are attacked by reactive oxygen species to produce 7,8-dihydro-8-oxoguanine (oxoG) and 7,8-dihydro-8-oxoadenine (oxoA) as major oxidative lesions. The high mutagenicity of oxoG is attributed to the lesion’s ability to adopt syn-oxoG:anti-dA with Watson-Crick-like geometry. Rec...
Tallennettuna:
| Julkaisussa: | Biochem J |
|---|---|
| Päätekijät: | , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2021
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8157797/ https://ncbi.nlm.nih.gov/pubmed/33881499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20210162 |
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