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Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4
Y-family DNA polymerases bypass Pt-GG, the cisplatin-DNA double-base lesion, contributing to the cisplatin resistance in tumour cells. To reveal the mechanism, we determined three structures of the Y-family DNA polymerase, Dpo4, in complex with Pt-GG DNA. The crystallographic snapshots show three st...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2892363/ https://ncbi.nlm.nih.gov/pubmed/20512114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.101 |
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