Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4

Y-family DNA polymerases bypass Pt-GG, the cisplatin-DNA double-base lesion, contributing to the cisplatin resistance in tumour cells. To reveal the mechanism, we determined three structures of the Y-family DNA polymerase, Dpo4, in complex with Pt-GG DNA. The crystallographic snapshots show three st...

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Detalhes bibliográficos
Main Authors: Wong, Jimson HY, Brown, Jessica A, Suo, Zucai, Blum, Paul, Nohmi, Takehiko, Ling, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2892363/
https://ncbi.nlm.nih.gov/pubmed/20512114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.101
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