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Mechanism of double-base lesion bypass catalyzed by a Y-family DNA polymerase
As a widely used anticancer drug, cis-diamminedichloroplatinum(II) (cisplatin) reacts with adjacent purine bases in DNA to form predominantly cis-[Pt(NH(3))(2){d(GpG)-N7(1),-N7(2)}] intrastrand cross-links. Drug resistance, one of the major limitations of cisplatin therapy, is partially due to the i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2475632/ https://ncbi.nlm.nih.gov/pubmed/18499711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn309 |
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