A Novel Mechanism of Sugar Selection Utilized by a Human X-family DNA Polymerase

During DNA synthesis, most DNA polymerases and reverse transcriptases select against ribonucleotides via a steric clash between the ribose 2′-hydroxyl group and the bulky side chain of an active site residue. Here, we demonstrated that human DNA polymerase λ used a novel sugar selection mechanism to...

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Autori principali: Brown, Jessica A., Fiala, Kevin A., Fowler, Jason D., Sherrer, Shanen M., Newmister, Sean A., Dyum, Wade W., Suo, Zucai
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2814876/
https://ncbi.nlm.nih.gov/pubmed/19900463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.11.003
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