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A Novel Mechanism of Sugar Selection Utilized by a Human X-family DNA Polymerase
During DNA synthesis, most DNA polymerases and reverse transcriptases select against ribonucleotides via a steric clash between the ribose 2′-hydroxyl group and the bulky side chain of an active site residue. Here, we demonstrated that human DNA polymerase λ used a novel sugar selection mechanism to...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2814876/ https://ncbi.nlm.nih.gov/pubmed/19900463 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.11.003 |
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