Identification of Critical Residues for the Tight Binding of Both Correct and Incorrect Nucleotides to Human DNA Polymerase λ

DNA polymerase λ (Pol λ) is a novel X-family DNA polymerase that shares 34% sequence identity with DNA polymerase β (Pol β). Pre-steady state kinetic studies have shown that the Pol λ•DNA complex binds both correct and incorrect nucleotides 130-fold tighter on average than the Pol β•DNA complex, alt...

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Detalhes bibliográficos
Main Authors: Brown, Jessica A., Pack, Lindsey R., Sherrer, Shanen M., Kshetry, Ajay K., Newmister, Sean A., Fowler, Jason D., Taylor, John-Stephen, Suo, Zucai
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957559/
https://ncbi.nlm.nih.gov/pubmed/20851705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.09.014
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