Pre-Steady-State Kinetic Analysis of the Incorporation of Anti-HIV Nucleotide Analogs Catalyzed by Human X- and Y-Family DNA Polymerases

Nucleoside reverse transcriptase inhibitors (NRTIs) are an important class of antiviral drugs used to manage infections by human immunodeficiency virus, which causes AIDS. Unfortunately, these drugs cause unwanted side effects, and the molecular basis of NRTI toxicity is not fully understood. Putati...

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Bibliografiska uppgifter
Huvudupphovsmän: Brown, Jessica A., Pack, Lindsey R., Fowler, Jason D., Suo, Zucai
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology (ASM) 2011
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019658/
https://ncbi.nlm.nih.gov/pubmed/21078938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01229-10
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