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Pre-Steady-State Kinetic Analysis of the Incorporation of Anti-HIV Nucleotide Analogs Catalyzed by Human X- and Y-Family DNA Polymerases

Nucleoside reverse transcriptase inhibitors (NRTIs) are an important class of antiviral drugs used to manage infections by human immunodeficiency virus, which causes AIDS. Unfortunately, these drugs cause unwanted side effects, and the molecular basis of NRTI toxicity is not fully understood. Putati...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Brown, Jessica A., Pack, Lindsey R., Fowler, Jason D., Suo, Zucai
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3019658/
https://ncbi.nlm.nih.gov/pubmed/21078938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01229-10
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