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Pre-Steady State Kinetic Investigation of the Incorporation of Anti-Hepatitis B Nucleotide Analogs Catalyzed by Non-Canonical Human DNA Polymerases

Antiviral nucleoside analogs have been developed to inhibit the enzymatic activities of the hepatitis B virus (HBV) polymerase, thereby preventing the replication and production of HBV. However, the usage of these analogs can be limited by drug toxicity because the 5′-triphosphates of these nucleosi...

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Hlavní autoři: Brown, Jessica A., Pack, Lindsey R., Fowler, Jason D., Suo, Zucai
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259259/
https://ncbi.nlm.nih.gov/pubmed/22132702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200458s
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