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Unlocking the Sugar ‘Steric Gate’ of DNA Polymerases
To maintain genomic stability, ribonucleotide incorporation during DNA synthesis is controlled predominantly at the DNA polymerase level. A steric clash between the 2′-hydroxyl of an incoming ribonucleotide and a bulky active site residue, known as the ‘steric gate’, establishes an effective mechani...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3040255/ https://ncbi.nlm.nih.gov/pubmed/21226515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi101915z |
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