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Unlocking the steric gate of DNA polymerase η leads to increased genomic instability in Saccharomyces cerevisiae

DNA polymerase η (pol η) is best characterized for its ability to perform accurate and efficient translesion DNA synthesis (TLS) through cyclobutane pyrimidine dimers (CPDs). To ensure accurate bypass the polymerase is not only required to select the correct base, but also discriminate between NTPs...

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Bibliografske podrobnosti
izdano v:DNA Repair (Amst)
Main Authors: Donigan, Katherine A., Cerritelli, Susana M., McDonald, John P., Vaisman, Alexandra, Crouch, Robert J., Woodgate, Roger
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4651834/
https://ncbi.nlm.nih.gov/pubmed/26340535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2015.07.002
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