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Structural insights into the bypass of the major deaminated purines by translesion synthesis DNA polymerase

The exocyclic amines of nucleobases can undergo deamination by various DNA damaging agents such as reactive oxygen species, nitric oxide, and water. The deamination of guanine and adenine generates the promutagenic xanthine and hypoxanthine, respectively. The exocyclic amines of bases in DNA are hyd...

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Pubblicato in:Biochem J
Autori principali: Jung, Hunmin, Hawkins, Michael A., Lee, Seongmin
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8138886/
https://ncbi.nlm.nih.gov/pubmed/33258913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20200800
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