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The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β
To provide molecular-level insights into the spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β (polβ), we report four crystal structures of polβ complexed with dG•dTTP and dA•dCTP mismatches in the presence of Mg(2+) or Mn(2+). The Mg(2+)-bound ground...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4176172/ https://ncbi.nlm.nih.gov/pubmed/25200079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku789 |
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