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The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β

To provide molecular-level insights into the spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β (polβ), we report four crystal structures of polβ complexed with dG•dTTP and dA•dCTP mismatches in the presence of Mg(2+) or Mn(2+). The Mg(2+)-bound ground...

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Detalhes bibliográficos
Main Authors: Koag, Myong-Chul, Nam, Kwangho, Lee, Seongmin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176172/
https://ncbi.nlm.nih.gov/pubmed/25200079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku789
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