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Double p52Shc/p46Shc Rat Knockout Demonstrates Severe Gait Abnormalities Accompanied by Dilated Cardiomyopathy

The ubiquitously expressed adaptor protein Shc exists in three isoforms p46Shc, p52Shc, and p66Shc, which execute distinctly different actions in cells. The role of p46Shc is insufficiently studied, and the purpose of this study was to further investigate its functional significance. We developed un...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Miller, Bradley, Kostrominova, Tatiana Y., Geurts, Aron M., Sorokin, Andrey
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155973/
https://ncbi.nlm.nih.gov/pubmed/34063460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105237
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