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Double p52Shc/p46Shc Rat Knockout Demonstrates Severe Gait Abnormalities Accompanied by Dilated Cardiomyopathy

The ubiquitously expressed adaptor protein Shc exists in three isoforms p46Shc, p52Shc, and p66Shc, which execute distinctly different actions in cells. The role of p46Shc is insufficiently studied, and the purpose of this study was to further investigate its functional significance. We developed un...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Miller, Bradley, Kostrominova, Tatiana Y., Geurts, Aron M., Sorokin, Andrey
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155973/
https://ncbi.nlm.nih.gov/pubmed/34063460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22105237
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