p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria

Although the p46Shc isoform has been known to be mitochondrially localized for 11 years, its function in mitochondria has been a mystery. We confirmed p46Shc to be mitochondrially localized and showed that the major mitochondrial partner of p46Shc is the lipid oxidation enzyme 3-ketoacylCoA thiolase...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Tomilov, Alexey, Tomilova, Natalia, Shan, Yuxi, Hagopian, Kevork, Bettaieb, Ahmed, Kim, Kyoungmi, Pelicci, Pier Giuseppe, Haj, Fawaz, Ramsey, Jon, Cortopassi, Gino
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Bioenergetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933453/
https://ncbi.nlm.nih.gov/pubmed/27059956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.695577
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