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Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.
Shc proteins are targets of activated tyrosine kinases and are implicated in the transmission of activation signals to Ras. The p46shc and p52shc isoforms share a C-terminal SH2 domain, a proline- and glycine-rich region (collagen homologous region 1; CH1) and a N-terminal PTB domain. We have isolat...
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Autors principals: | , , , , , , , , , |
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Format: | Artigo |
Idioma: | Inglês |
Publicat: |
1997
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1169672/ https://ncbi.nlm.nih.gov/pubmed/9049300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.4.706 |
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