The p52 isoform of SHC1 is a key driver of breast cancer initiation

BACKGROUND: SHC1 proteins (also called SHCA) exist in three functionally distinct isoforms (p46SHC, p52SHC, and p66SHC) that serve as intracellular adaptors for several key signaling pathways in breast cancer. Despite the broad evidence implicating SHC1 gene products as a central mediator of breast...

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Dades bibliogràfiques
Publicat a:Breast Cancer Res
Autors principals: Wright, Kevin D., Miller, Bradley S., El-Meanawy, Sarah, Tsaih, Shirng-Wern, Banerjee, Anjishnu, Geurts, Aron M., Sheinin, Yuri, Sun, Yunguang, Kalyanaraman, Balaraman, Rui, Hallgeir, Flister, Michael J., Sorokin, Andrey
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570928/
https://ncbi.nlm.nih.gov/pubmed/31202267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-019-1155-7
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