Identification of a Rat Mammary Tumor Risk Locus That Is Syntenic with the Commonly Amplified 8q12.1 and 8q22.1 Regions in Human Breast Cancer Patients

Breast cancer risk is 31% heritable, yet the majority of the underlying risk factors remain poorly defined. Here, we used F2-linkage analysis in a rat mammary tumor model to identify a novel 11.2 Mb modifier locus of tumor incidence and burden on rat chromosome 5 (chr5: 15.4 – 26.6 Mb). Genomic and...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:G3 (Bethesda)
Egile Nagusiak: Plasterer, Cody, Tsaih, Shirng-Wern, Lemke, Angela, Schilling, Rebecca, Dwinell, Melinda, Rau, Andrea, Auer, Paul, Rui, Hallgeir, Flister, Michael J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Genetics Society of America 2019
Gaiak:
Investigations
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6505137/
https://ncbi.nlm.nih.gov/pubmed/30914425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.118.200873
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