Identifying multiple causative genes at a single GWAS locus

Genome-wide association studies (GWAS) are useful for nominating candidate genes, but typically are unable to establish disease causality or differentiate between the effects of variants in linkage disequilibrium (LD). Additionally, some GWAS loci might contain multiple causative variants or genes t...

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Detalhes bibliográficos
Main Authors: Flister, Michael J., Tsaih, Shirng-Wern, O'Meara, Caitlin C., Endres, Bradley, Hoffman, Matthew J., Geurts, Aron M., Dwinell, Melinda R., Lazar, Jozef, Jacob, Howard J., Moreno, Carol
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847770/
https://ncbi.nlm.nih.gov/pubmed/24006081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.160283.113
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