Identifying multiple causative genes at a single GWAS locus

Genome-wide association studies (GWAS) are useful for nominating candidate genes, but typically are unable to establish disease causality or differentiate between the effects of variants in linkage disequilibrium (LD). Additionally, some GWAS loci might contain multiple causative variants or genes t...

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Détails bibliographiques
Auteurs principaux: Flister, Michael J., Tsaih, Shirng-Wern, O'Meara, Caitlin C., Endres, Bradley, Hoffman, Matthew J., Geurts, Aron M., Dwinell, Melinda R., Lazar, Jozef, Jacob, Howard J., Moreno, Carol
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2013
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847770/
https://ncbi.nlm.nih.gov/pubmed/24006081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.160283.113
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