Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists

[Image: see text] The PD-1/PD-L1 axis has proven to be a highly efficacious target for cancer immune checkpoint therapy with several approved antibodies. Also, small molecules based on a biphenyl core can antagonize PD-1/PD-L1, leading to the in vitro formation of PD-L1 dimers. However, their develo...

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Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Butera, Roberto, Ważyńska, Marta, Magiera-Mularz, Katarzyna, Plewka, Jacek, Musielak, Bogdan, Surmiak, Ewa, Sala, Dominik, Kitel, Radoslaw, de Bruyn, Marco, Nijman, Hans W., Elsinga, Philip H., Holak, Tad A., Dömling, Alexander
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2021
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155249/
https://ncbi.nlm.nih.gov/pubmed/34055224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00033
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