Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis

[Image: see text] Structure–activity relationship studies directed toward the replacement of the fused phenyl ring of the lead hexahydrobenzoindole RORγt inverse agonist series represented by 1 with heterocyclic moieties led to the identification of three novel aza analogs 5–7. The hexahydropyrrolo[...

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Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Liu, Qingjie, Xiao, Hai-Yun, Batt, Douglas G., Xiao, Zili, Zhu, Yeheng, Yang, Michael G., Li, Ning, Yip, Shiuhang, Li, Peng, Sun, Dawn, Wu, Dauh-Rurng, Ruzanov, Max, Sack, John S., Weigelt, Carolyn A., Wang, Jinhong, Li, Sha, Shuster, David J., Xie, Jenny H., Song, Yunling, Sherry, Tara, Obermeier, Mary T., Fura, Aberra, Stefanski, Kevin, Cornelius, Georgia, Chacko, Silvi, Khandelwal, Purnima, Dudhgaonkar, Shailesh, Rudra, Anjuman, Nagar, Jignesh, Murali, Venkata, Govindarajan, Arun, Denton, Rex, Zhao, Qihong, Meanwell, Nicholas A., Borzilleri, Robert, Dhar, T. G. Murali
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2021
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155243/
https://ncbi.nlm.nih.gov/pubmed/34055233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00112
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